NADPH diaphorase detects S-nitrosylated proteins in aldehyde-treated biological tissues
نویسندگان
چکیده
منابع مشابه
Proteomic analysis of S-nitrosylated proteins in mesangial cells.
NO participates in numerous biological events in a variety of cell types including activated glomerular mesangial cells. Many of these events appear to be independent of the known effects of NO on soluble guanylyl cyclase. NO derived from all major isoforms of NO synthase can S-nitrosylate cysteine residues in target proteins, potentially altering their functional activities. Recent evidence su...
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Although nitric oxide (NO) has grown into a key signaling molecule in plants during the last few years, less is known about how NO regulates different events in plants. Analyses of NO-dependent processes in animal systems have demonstrated protein S-nitrosylation of cysteine (Cys) residues to be one of the dominant regulation mechanisms for many animal proteins. For plants, the principle of S-n...
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INTRODUCTION AND METHODS. Nitric oxide (NO) has recently emerged as a major modulator of carotid body (CB) chemoreception. This is evidenced by functional and morphological studies. Chemosensory activity is inhibited by NO agonists and disinhibited by antagonists in both in situ and in vitro preparations (1, 2). At the light microscopic level, the NADPH-diaphorase (NADPH-d)/nitric oxide synthas...
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NADPH diaphorase staining neurons, uniquely resistant to toxic insults and neurodegenerative disorders, have been colocalized with neurons in the brain and peripheral tissue containing nitric oxide synthase (EC 1.14.23.-), which generates nitric oxide (NO), a recently identified neuronal messenger molecule. In the corpus striatum and cerebral cortex, NO synthase immunoreactivity and NADPH diaph...
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Neurons in the monkey cerebral cortex containing nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) can be divided into two distinct types, both nonpyramidal. Type I neurons have a large soma (diameter 20-50 microm), a dense NADPH-d histochemical reaction, and are distributed throughout the cortex, but mainly in the subcortical white matter, and are mostly aspiny. Type II cells ha...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2020
ISSN: 2045-2322
DOI: 10.1038/s41598-020-78107-6